Process for preparing 4-substituted azetidinone derivatives

Details Process for preparing 4-substituted azetidinone derivatives Process for preparing 4-substituted azetidinone derivatives

1996-06-10

1998-03-24

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20508, C07D41306, C07D40306, C07D41706

Patent

active

057314314

ABSTRACT:
A process for preparing 4-substituted azetidinone derivatives of the formula: ##STR1## wherein R is hydrogen or an easily removable protecting group; R.sup.1 is alkyl which can be substituted by hydroxy which can be protected or halogen; R.sup.2 is hydrogen or alkyl; R.sup.3 is alkyl, trialkylsilyl, phenyl which can be substituted by alkyl, alkoxy, nitro or halogen, cycloalkyl, naphthyl, anthracenyl, fluorenyl, benzothiazolyl or naphthalimidyl; and R.sup.4 is an electron withdrawing group or can form a ring together with R.sup.3, which comprises reacting an azetidinone derivative of the formula: ##STR2## wherein R and R.sup.1 are as defined above, and Z is a leaving group, and an imide compound of the formula: ##STR3## wherein R.sup.2, R.sup.3 and R.sup.4 are as defined above, in the presence of a titanium compound of the formula:

REFERENCES:
patent: 5442055 (1995-08-01), Iwasaki
patent: 5550229 (1996-08-01), Iwasaki
Mukaiyamo, Chem. Let. 1986, 915.
Abstract of Japanese Patent No. 60019764 (1985).
Abstract of JP 56-142259 (1981).
Abstract JP 55-7251 (1980).

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