Process for preparing 4-hydroxypyrimidine

Details Process for preparing 4-hydroxypyrimidine Process for preparing 4-hydroxypyrimidine

1989-01-23

1990-06-19

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23934

Patent

active

049355163

ABSTRACT:
A process for preparing a 4-hydroxypyrimidine of Formula III: ##STR1## wherein R.sub.1 and R.sub.2 each represent a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, a cycloalkyl group having 3 to 10 carbon atoms or an aralkyl group having 2 to 10 carbon atoms, and R.sub.4 represents hydrogen an alkyl group having 1 to 10 carbon atoms, a cycloalkyl group having 3 to 10 carbon atoms, an aralkyl group having 7 to 10 carbon atoms or an aryl group having 6 to 10 carbon atoms, which comprises subjecting a 3-amino-2-unsaturated carboxylate of Formula I: ##STR2## wherein R.sub.1 and R.sub.2 are as defined above and R.sub.3 represents an alkyl group having 1 to 10 carbon atoms, a cycloalkyl group having 3 to 10 carbon atoms or an aralkyl group having 7 to 10 carbon atoms, and a carboxylic acid amide of Formula II:

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