Process for preparing 4-aminopyrimidine compound

Details Process for preparing 4-aminopyrimidine compound Process for preparing 4-aminopyrimidine compound

2005-10-28

2009-11-17

Wilson, James O (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

active

07619084

ABSTRACT:
The present invention is to provide a process for preparing a 4-aminopyrimidine compound represented by the formula (3):wherein R1and R2each represent a hydrogen atom or group which does not participate in the reaction and which may have a substituent(s), and R1and R2may be bonded to each other to form a ring, and R4represents a hydrogen atom or a hydrocarbon group,which comprises reacting ammonia, a 3-substituted or unsubstituted acrylonitrile compound represented by the formula (1):in-line-formulae description="In-line Formulae" end="lead"?CR1(CN)═CR2Y  (1)in-line-formulae description="In-line Formulae" end="tail"?wherein R1and R2have the same meanings as defined above, and Y represents an amino group or OR, where R represents a hydrogen atom or a hydrocarbon group,and an organic acid compound represented by the formula (2):in-line-formulae description="In-line Formulae" end="lead"?(R3O)3CR4  (2)in-line-formulae description="In-line Formulae" end="tail"?wherein R3represents a hydrocarbon group, and R4has the same meaning as defined above.

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Dörwald, F. Zaragoza. Side Reactions in Organic Synthesis: A Guide to Successful Synthesis Design, Weinheim: Wiley-VCH Verlag GmbH & Co. KGaA, 2005, Preface.

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