Process for preparing 4-alkyl- or 4-aryl-oxycarbonyl...

Details Process for preparing 4-alkyl- or 4-aryl-oxycarbonyl... Process for preparing 4-alkyl- or 4-aryl-oxycarbonyl...

2006-04-18

2006-04-18

Dentz, Bernard (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S214000

Reexamination Certificate

active

07030253

ABSTRACT:
A process is provided for preparing 4-alkyl- or 4-aryl-oxycarbonyl paclitaxel analogs which includes the steps of converting paclitaxel into a C-7 acylprotected paclitaxel employing an electrophilic protecting group, such as benzoyloxycarbonyl, and converting the C-7 protected analog into the 4-alkyloxycarbonyl or 4-aryloxycarbonyl paclitaxel analog. Novel intermediates produced in the process are also provided.

REFERENCES:
patent: 5175315 (1992-12-01), Holton
patent: 5227400 (1993-07-01), Holton et al.
patent: 5229526 (1993-07-01), Holton
patent: 6020507 (2000-02-01), Gibson
patent: 6476242 (2002-11-01), Kingston et al.
patent: 6515151 (2003-02-01), Poss et al.
Greene, T. W. et al., Protective Groups in Organic Synthesis, Second Edition, John Wiley & Sons, Inc., publ., pp. ix-x (table of contents) (1991).

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