Process for preparing 4-acetoxy-3-hydroxyethylazetidin-2-one der

Details Process for preparing 4-acetoxy-3-hydroxyethylazetidin-2-one der Process for preparing 4-acetoxy-3-hydroxyethylazetidin-2-one der

1989-02-14

1990-04-03

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D20508, C07B 4112

Patent

active

049142003

ABSTRACT:
A process for preparing a 4-acetoxy-3-hydroxyethylazetidin-2-one derivative having the formula (II): ##STR1## wherein R.sup.1 is a protective group for the hydroxyl group, which comprises reacting a .beta.-lactam compound having the formula (I): ##STR2## wherein R.sup.1 is as defined above, and R.sup.2, R.sup.3 and R.sup.4 are a lower alkyl group having 1 to 6 carbon atoms, phenyl group or an aralkyl group, with acetic anhydride in an organic solvent in the presence of a low concentration of a substituted pyridine. According to the present invention, there can be obtained 4-acetoxy-3-hydroxyethylazetidin-2-one derivatives, which are useful intermediates for preparing carbapenem .beta.-lactam antibiotics.

REFERENCES:
Fuchs et al., Chem. Ber. 107, 721-4 (1974).
Yoshida et al., Chemical and Pharmaceutical Bulletin, vol. 29, No. 10, Oct. 1981; pp. 2899-2909.
Shiozaki et al., Tetrahedron, vol. 39, No. 13, 1983, pp. 2399-2407.
Chiba et al., Chemistry Letters, No. 7, 1984, pp. 1927-1930.
Wetter et al., Tetrahedron Letters, vol. 26, No. 45, 1985, pp. 5515-5518.

Affiliated with

Also associated with

Rating

Process for preparing 4-acetoxy-3-hydroxyethylazetidin-2-one der does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing 4-acetoxy-3-hydroxyethylazetidin-2-one der, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing 4-acetoxy-3-hydroxyethylazetidin-2-one der will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1358305