Process for preparing 4-acetoxy-3-hydroxyethylazetidin-2-one der

Details Process for preparing 4-acetoxy-3-hydroxyethylazetidin-2-one der Process for preparing 4-acetoxy-3-hydroxyethylazetidin-2-one der

1988-02-18

1990-04-03

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D20508, C07F 718, C07B 4112

Patent

active

049141996

ABSTRACT:
A process for preparing a 4-acetoxy-3-hydroxyethylazetidin-2-one derivative having the formula (II): ##STR1## wherein R.sup.1 is a protective group for the hydroxyl group, which comprises reactig a .beta.-lactam compound having the formula (I): ##STR2## wherein R.sup.1 is as difined above and R.sup.2, R.sup.3 and R.sup.4 are the same or different and each is a lower alkyl group having 1 to 4 carbon atoms or an aralkyl group, with acetic anhydride in the presence of a base and a catalyst selected from the group consisting of an organic strong acid, a mineral acid, a Lewis acid, a halogenated acyl compound having the formula (IV):

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