Process for preparing 4.6-bis(difluoromethoxy)pyrimidine derivat

Details Process for preparing 4.6-bis(difluoromethoxy)pyrimidine derivat Process for preparing 4.6-bis(difluoromethoxy)pyrimidine derivat

1997-07-15

1999-01-05

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

F07D23960

Patent

active

058564837

ABSTRACT:
A process for preparing 4,6-bis(difluoromethoxy)pyrimidine derivatives of the general formula: ##STR1## wherein R is a C.sub.1-4 -alkyl or optionally substituted phenyl or benzyl, proceeding from the corresponding 4,6-dihydroxypyrimidine dialkali-metal salt. In the process, the educt is reacted under pressure with chlorodifluoromethane in a solvent selected from the group consisting of the ketones, in the presence of a base and a phase-transfer catalyst and in the presence of 40 to 100 mol per mol of water of the 4,6-dihydroxypyrimidine dialkali-metal salt to form the final product.

REFERENCES:
patent: 4692524 (1987-09-01), Hassig
patent: 4900827 (1990-02-01), Seifert et al.

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