Process for preparing 4,5,6,7-tetrahydro-7-oxobenzo[b]thiophenes

Details Process for preparing 4,5,6,7-tetrahydro-7-oxobenzo[b]thiophenes Process for preparing 4,5,6,7-tetrahydro-7-oxobenzo[b]thiophenes

1977-11-16

1982-06-01

Siegel, Alan

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

549 51, 560 28, 564 45, 564 44, 564 48, 564161, 564166, 564176, 564215, 548465, 548473, 548527, 548545, 548548, C07D20934, C07D20724, C07D33324, C07C12506

Patent

active

043327249

ABSTRACT:
There is provided a process for the preparation of an amido or an ureido derivative of certain 4,5,6,7-tetrahydro-7-oxobenzo[b]thiophenes or certain 1,2,3,4-tetrahydro-4-oxonaphthalenes which can be employed as an animal growth regulant. The process comprises: oxidizing in the presence of a cobalt catalyst a compound having the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each a substituent selected from the group consisting of alkanoyl C.sub.1 -C.sub.7, halogen-substituted alkanoyl C.sub.1 -C.sub.7, carboalkoxy C.sub.1 -C.sub.4, ##STR2## and ##STR3## R.sub.3 is selected from the group consisting of hydrogen and alkyl C.sub.1 -C.sub.4 ; R.sub.4 is selected from the group consisting of hydr ogen, alkyl C.sub.1 -C.sub.8, alkanoyl C.sub.2 -C.sub.4, halogen-substituted alkanoyl (C.sub.2 -C.sub.4), and ##STR4## and when the ##STR5## moiety is cyclized each represents a moiety selected from the group consisting of succinimido, maleimido and phthalimido; X and Y are each a radical selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, nitro, alkyl C.sub.1 -C.sub.4 ; the racemic mixtures and the optical isomers thereof.

REFERENCES:
patent: 3546303 (1970-12-01), Hornberger
patent: 3994924 (1976-11-01), Asato
House "Modern Synthesis Reactions", 2nd ed. (1972), p. 278.

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