Process for preparing 4,4-dialkyl-6-halo-chromans or thiochroman

Details Process for preparing 4,4-dialkyl-6-halo-chromans or thiochroman Process for preparing 4,4-dialkyl-6-halo-chromans or thiochroman

1995-03-01

1996-05-21

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D31158

Patent

active

055191509

ABSTRACT:
A process of preparing intermediates useful in making compounds with retinoic acid-like activity is disclosed. The intermediates are halogenated chromans and thiochromans of the formula shown below and are prepared by the alkylation of a phenol or thiophenol with an alkene compound (the starting materials shown in the formula below), cyclization and halogenation. ##STR1## In the formula the symbols have the following meanings: R.sub.1 and R.sub.2 are C.sub.1 to C.sub.4 alkyl, R.sub.3 is H or C.sub.1 to C.sub.4 alkyl, X is oxygen or sulfur, Y is a leaving group, and Z is chlorine, bromine or iodine.

REFERENCES:
patent: 4739098 (1988-04-01), Chandraratna
patent: 4810804 (1989-03-01), Chandraratna
patent: 5023341 (1991-06-01), Chandraratna
patent: 5089509 (1992-02-01), Chandraratna
patent: 5162546 (1992-11-01), Chandraratna

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