Process for preparing 4-(2,4-difluorophenyl)-salicyclic acid

Details Process for preparing 4-(2,4-difluorophenyl)-salicyclic acid Process for preparing 4-(2,4-difluorophenyl)-salicyclic acid

1978-05-11

1980-09-30

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

260649F, 560130, 568319, 568331, C07C 6976

Patent

active

042257301

ABSTRACT:
5-(2,4-difluorophenyl)salicylic acid, an anti-inflammatory, anti-pyretic, analgesic agent is prepared by: (1) diazotizing 2,4-difluoroaniline in the presence of benzene to yield 2,4-difluorobiphenyl; (2) Friedel-Crafts acylation to produce 2',4'-difluoro-4-alkanoylbiphenyl; (3) oxidation of the alkanoyl group to produce 2',4'-difluoro-4-alkanoyloxybiphenyl; (4) hydrolysis of the alkanoyl group to produce 4-(2,4-difluorophenyl)phenol; and (5) Kolbe-Schmitt carboxylation to produce the final product.

REFERENCES:
patent: 3681445 (1972-08-01), Ruyle

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