Process for preparing 3alpha, 7beta-dihydroxy-5beta-cholanic aci

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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C07J 7100

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044863527

ABSTRACT:
Process to reduce stereoselectively 3alpha-hydroxy-7-keto-5beta-cholanic acid to 3alpha,7beta-dihydroxy-5beta-cholanic acid in ter.alcohols by using, as reducing agent, sodium metal in the presence of other metal salts.
Examples of metal salts particularly useful are: potassium, cesium and rhubidium organic salts and, more particularly, potassium acetate or potassium ter.butylate.

REFERENCES:
patent: 4282161 (1981-08-01), Guillemette et al.
patent: 4337206 (1982-06-01), Gargani et al.
patent: 4379093 (1983-04-01), Bonaldi et al.

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