Process for preparing...

Details Process for preparing... Process for preparing...

2005-05-31

2005-05-31

Berch, Mark L. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S317000

Reexamination Certificate

active

06900316

ABSTRACT:
A process for preparing a 2-(pyridin-4-ylamino)-pyrido[2,3-d]pyrimidine of Formula IIcomprising reacting a 4-aminopyridine of the formulawith an alkali metal amide or hydride and a 2-alkylsulfanyl-pyrido[2,3-d]pyrimidine of Formula Iwherein R1, R2, R′ and R″, and aryl are as defined in the specification.

REFERENCES:
patent: 5733914 (1998-03-01), Blankley et al.
patent: 5945422 (1999-08-01), Doherty et al.
patent: 2003/0149001 (2003-08-01), Barvian et al.
patent: 2003/0216415 (2003-11-01), Beylin et al.
patent: 2003/0220345 (2003-11-01), Hamby et al.
patent: WO 96/34867 (1996-11-01), None
patent: WO 01/44258 (2001-06-01), None
Andrew M. Thompson, et al., “Tyrosine kinase inhibitors. 7.7-amino-4-(phenylamino)- and 7-amino-4-[(phenylmethyl)amino]pyrido[4,3-d]pyrimidines: a new class of inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor” J. Med. Chem, 1995, pp 3780—3788, vol. 38, No 19.
S. R. Klutchko, et al., “2-Substituted Aminopyrido[2,3-d]pyrimidin-7(8H)-ones. Structure Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity”, J. Med. Chem., 1998, pp 3276-3292, vol. 41.
D. H. Boschelli, et al., “Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selcetive Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors” J. Med. Chem, 1998, pp 4365-4377, vol. 41.

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