Process for preparing 3-substituted-methyl-3-cephem derivatives

Details Process for preparing 3-substituted-methyl-3-cephem derivatives Process for preparing 3-substituted-methyl-3-cephem derivatives

1985-02-08

1987-10-13

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540222, C07D50118, A61K 31545

Patent

active

046999809

ABSTRACT:
Various 7-amino-3-substituted-methyl-3-cephem-4-carboxylic acids and lower alkylsilyl derivatives such as 7-amino-3-(2,3-cyclopenteno-1-pyridiniomethyl)-3-cephem-4-carboxylic acid iodide and trimethylsilyl 7-trimethyl-silylamino-3-(5,6,7,8-tetrahydro-2-isoquinoliniomethyl)-3-ceph em-4-carboxylate iodide are valuable intermediates in the preparation of new and novel antibacterial agents. A new process for the preparation of these acids and the derivatives has been devised.

REFERENCES:
patent: 4012379 (1977-03-01), Numata et al.
patent: 4366315 (1982-12-01), Bruynes
patent: 4518747 (1985-05-01), Treadgold
patent: 4558124 (1985-12-01), Corfield

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