Process for preparing 3-pyrrolidinols

Details Process for preparing 3-pyrrolidinols Process for preparing 3-pyrrolidinols

1988-01-11

1991-02-05

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

558393, 558451, C07C25512, C07C25536

Patent

active

049906836

ABSTRACT:
A novel process is disclosed for the preparation of 3-pyrrolidinol compounds selected from the group having the formula: ##STR1## wherein: R is selected from hydrogen, loweralkyl, loweralkenyl, cycloalkyl, cycloalkyl-loweralkyl, phenyl-loweralkyl and substituted phenyl-loweralkyl; R.sup.1, R.sup.2, and R.sup.3 are selected from hydrogen, loweralkyl, and loweralkenyl; and the optical isomers thereof. In the process, 4-amino-3-hydroxybutyronitriles are reductively cyclized with Raney nickel to produce the 3-pyrrolidinol compound.

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Massie, C. A., 41, (1947), 3044(b).
Jung, et al., 102, J.A.C.S., (1980), pp. 6304-6311.

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