Process for preparing 3-pyrrolidinol

Details Process for preparing 3-pyrrolidinol Process for preparing 3-pyrrolidinol

1989-06-21

1990-03-20

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20712

Patent

active

049103202

ABSTRACT:
A process for preparing 3-pyrrolidinol having the formula (II): ##STR1## or a salt thereof, which comprises reducing 4-chloro-3-hydroxybutyronitrile having the formula (I): ##STR2## to convert said 4-chloro-3-hydroxybutyronitrile (I) into said 3-pyrrolidinol (II). According to the present invention, 3-pyrrolidinol, particularly optically active 3-pyrrolidinol can be prepared economically and efficiently.

REFERENCES:
patent: 3542807 (1970-11-01), Lansford et al.
patent: 3577415 (1971-05-01), Cale
Brown, Herbert C. et al., "Hydroboration, 78, Reinvestigation of the Hydroboration of N-Substituted-3-pyrrolines, Preparation of N-Benzyl-3-pyrrolidinol and (N-Benzyl-3-pyrrolidinyl)boronate of Very High Enantiomeric Purity," Journal of Organic Chemistry, vol. 51 (1986) pp. 4296-4298.
Nemia, Margaret M. Bowers et al., "Synthetic Routes to 3-Pyrrolidinol," Synthetic Communications, vol. 13 (1983) pp. 1117-1123.
Bhat, Krishna L. et al., "Synthetic Routes to Chiral 3-Pyrrolidinols," Synthetic Communications, vol. 15 (1985) pp. 587-598.
Hashimoto, Mitsunori et al., "A Novel Decarboxylation of .alpha.-Amino Acids, A Facile Method of Decarboxylation by the Use of 2-Cyclohexene-1-One as a Catalyst," Chemistry Letters, (1986) pp. 893-896.
Binon, F. et al., "Contribution a l'Etude de Derives de la Carnitine et de la Betaine Crotonique," Bull. Soc. Chim. Belg., vol. 72 (1963) pp. 166-177.
Kurtz, Peter et al., "Uber 1-Cyan-alkene-(2)," Liebig Annalen, vol. 631 (1960) pp. 21-57.

Affiliated with

Also associated with

Rating

Process for preparing 3-pyrrolidinol does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing 3-pyrrolidinol, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing 3-pyrrolidinol will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-793904