Process for preparing 3-hydroxymethyl cephalosporins

Details Process for preparing 3-hydroxymethyl cephalosporins Process for preparing 3-hydroxymethyl cephalosporins

1975-02-18

1976-10-12

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

195 80R, 260240J, 424246, C07D50104

Patent

active

039857425

ABSTRACT:
Disclosed are 7.beta.-(D-5-amino-5-carboxyvaleramido)-7-methoxy-3-cephem-4-carboxylic acids which are substituted in the three position of the "cephem" nucleus by a variety of alkyl, haloalkyl or oxygen, sulfur and nitrogen containing substituents; and the salts, esters and amide derivatives thereof. Certain of the products are obtained by fermentation and others are obtained by synthetic means. The products exhibit activity against gram-negative and gram-positive bacteria.

REFERENCES:
patent: 3668202 (1972-06-01), Foster et al.
patent: 3883518 (1975-05-01), Ponticello et al.

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