Process for preparing 3-hydroxy-ML-236B derivatives known as M-4

Details Process for preparing 3-hydroxy-ML-236B derivatives known as M-4 Process for preparing 3-hydroxy-ML-236B derivatives known as M-4

1982-11-18

1985-08-27

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435135, 435253, 435872, C12P 742, C12P 762, C12N 120

Patent

active

045378592

ABSTRACT:
Compounds of formula (I): ##STR1## (wherein OH represents OH or OH), that is to say M-4 carboxylic acid and M-4' carboxylic acid, as well as pharmaceutically acceptable salts and esters thereof and the corresponding ring-closed lactones may be prepared by contacting an ML-236B compound with a microorganism of the genus Nocardia or a cell-free, enzyme-containing extract thereof and then, if necessary, subjecting the resulting product to one or more of the following reactions: hydrolysis, salification, esterification and lactonisation. The resulting M-4 and M-4' derivatives have the ability to inhibit the biosynthesis of cholesterol and are therefore of value in the therapy and/or prophylaxis of hyperlipaemia and arteriosclerosis.

REFERENCES:
patent: 3281330 (1966-10-01), Fonken et al.
patent: 3392171 (1968-07-01), Fonken et al.
patent: 4410629 (1983-10-01), Terahara et al.

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