Process for preparing 3 halogeno-2-hydroxypropyltrimethylammoniu

Details Process for preparing 3 halogeno-2-hydroxypropyltrimethylammoniu Process for preparing 3 halogeno-2-hydroxypropyltrimethylammoniu

1987-08-21

1989-03-21

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564296, C07C 8506

Patent

active

048145068

ABSTRACT:
A process for preparing 3-halogeno-2-hydroxy-propyltrimethylammonium halide or especially one having the (S)-configuration, which comprises reacting 2,3-dihydroxypropyltrimethylammonium halide or one having the (S)-configuration, which is obtained by reacting (R)-3-halogeno-1,2-propanediol with trimethylamine, with a halogenating reagent.
According to the present invention, 3-halogeno-2-hydroxypropyltrimethylammonium halide or one having the (S)-configuration, which is a useful intermediate for the synthesis of carnitine or especially (l)-carnitine, can be obtained economically, efficiently and easily.

REFERENCES:
patent: 3135788 (1964-06-01), Noguchi et al.
patent: 3721650 (1973-03-01), DAlelio
patent: 4594452 (1986-06-01), Reimschuessel et al.
patent: 4709059 (1987-11-01), Dirlikor et al.
Houben-Weyl, Methoden der organischen Chemie, vol. V/3 "Halogenverbindungen", pp. 830-837, George Thieme Verlag.
Baldwin et al., J. Org. Chem., vol. 43, No. 25, pp. 4876-4878 (1978).
Kan et al., Agric. Biol. Chem., 49 (6) 1669-1674 (1985).

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