Process for preparing 3-fluoro-D-alanine and its deutero analogs

Details Process for preparing 3-fluoro-D-alanine and its deutero analogs Process for preparing 3-fluoro-D-alanine and its deutero analogs

1974-11-20

1976-08-24

Raymond, Richard L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26032611R, 260518A, 260534R, C07C 9900, C07C10110

Patent

active

039766896

ABSTRACT:
3-Fluoro-D-alanine and its deutero analogs, which are potent antibacterial agents, are prepared from fluoropyruvic acid by asymmetric synthesis using an optically active amine such as D-.alpha.-methyl-benzylamine.

REFERENCES:
patent: 2610212 (1952-09-01), Floyd
patent: 2839547 (1958-06-01), Berther
Adams, Organic Reactions, vol. 7, John Wiley & Sons, Inc., New York (1948) pp. 275 and 276.
Ginsburg, Concerning Amines, Pergamon Press, New York, (1967) pp. 33 to 35.

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