Process for preparing 3-carbamoyloxymethyl cephalosporins

Details Process for preparing 3-carbamoyloxymethyl cephalosporins Process for preparing 3-carbamoyloxymethyl cephalosporins

1980-01-15

1981-08-18

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 16, 544 21, C07D50104

Patent

active

042847672

ABSTRACT:
A process for the preparation of a 3-carbamoyloxymethyl cephalosporin compound which comprises reacting a 3-hydroxymethyl cephalosporin with dihalophosphinyl isocyanate and converting the resulting 3-phosphonocarbamoyloxymethyl cephalosporin reaction product by hydrolysis to the desired compound. The isocyanates used in the process are readily available and easy to handle and thus the process avoids the use of hazardous and/or expensive reagents.

REFERENCES:
patent: 3355452 (1967-11-01), Urech et al.
patent: 3875152 (1975-04-01), Sellstedt
patent: 3905967 (1975-09-01), Webber
patent: 4043991 (1975-08-01), Hamma et al.
Lapidot et al., J. Chem. Soc., (1958), pp. 1713-1717.
Shokol et al., Chemical Abstracts, vol. 73, 14927b (1970).
Cotton et al., Advanced Inorganic Chemistray, (1967), pp. 506-508.

Affiliated with

Also associated with

Rating

Process for preparing 3-carbamoyloxymethyl cephalosporins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing 3-carbamoyloxymethyl cephalosporins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing 3-carbamoyloxymethyl cephalosporins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-38533