Process for preparing 3,4-dioxo-substituted aromatic aldehydes

Details Process for preparing 3,4-dioxo-substituted aromatic aldehydes Process for preparing 3,4-dioxo-substituted aromatic aldehydes

2006-07-25

2009-06-09

Witherspoon, Sikarl A (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

Reexamination Certificate

active

07544843

ABSTRACT:
A new process for synthesizing 3,4-dioxo-substituted aromatic aldehydes by Oppenauer oxidation of the corresponding benzyl alcohols is described. The process, which specifically uses formaldehyde as hydrogen acceptor, proceeds with unexpectedly high yields and conversion percentages, allowing low cost access to finished and intermediate products of high industrial interest in the field of pharmaceutical products and fragrances.

REFERENCES:
patent: 4663488 (1987-05-01), Locko et al.
patent: 6703527 (2004-03-01), Tanikawa et al.
Creyghton, et al. (1997) “Stereoselective Meerwein-Ponndort-Verley and Oppenauer Reactions Catalysed by Zeolite BEA”;Journal of Molecular Catalysis A: Chemical; 115:457-472.
Djerassi, C. (1951) “The Oppenauer Oxidation”;Organic Reactions; vol. VI; Chapter 5; 207-272.
Graauw et al. (1994) “Meerwein-Ponndort-Verley Reductions and Oppenauer Oxidations: An Integrated Approach; Synthesis”;1007-1017.
Grigor'ev, et al. (1989) “Use of 1-Hydroxybenzotriazole-Based Polymeric Activated Esters in Peptide Synthesis”;Zhumal Organicheskoi khimii; 25:1963-1967.
Hon, et al. (2004) “Tishchenko reactions and Oppenauer oxidation reactions of aldehydes promoted by diisobutylaluminum hydride”:Tetrahedron Letters: 45:3313-3315.
International Preliminary Report on Patentability for PCT/EP2006/064622.
Lin, et al. (1952) “A Study of the Mixed Tischtschenko Reaction”:Contribution from the Department of Chemistry of the University of Pennsylvania: 5133-5135.
March, J. (1977) “Aromatic Electrophilic Substitution”:Advanced Organic Chemistry; 419-420; McGraw-Hill; Texas, US.
Marie-Robert De Maheas, M.R. (1989-1999) “La Réation de A. Vilsmeier et A. Haack”;Mise Au Point; Article in French.

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