Process for preparing 2-thiouracil nucleosides

Details Process for preparing 2-thiouracil nucleosides Process for preparing 2-thiouracil nucleosides

1974-01-07

1976-08-17

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, C07H 1702

Patent

active

039753743

ABSTRACT:
Some new 1-(2- or 3-deoxy-.beta.-D-pentofuranosyl)-2-thiouracils and 1-.beta.-D-pentofuranosyl-2-thio-6-azauracils have been prepared. Further, it has been found that the known nucleoside compound, 1-.beta.-D-ribofuranosyl-2-thiouracil is active against Herpes virus and against L-1210 leukemia in mice. An improved method of preparing corresponding 2-0-methyluracil and 2-0-methyl-6-azauracil intermediates is described. The method preserves the .beta.-configuration of the starting nucleoside.

REFERENCES:
patent: 3463850 (1969-08-01), Shen et al.
patent: 3708469 (1963-01-01), Vorbruggen et al.

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