Process for preparing 2-thioadenosine

Details Process for preparing 2-thioadenosine Process for preparing 2-thioadenosine

1975-07-14

1976-11-02

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1922

Patent

active

039896820

ABSTRACT:
A process for preparing 2-thioadenosine, useful as an intermediate for the preparation of S-substituted-2-thioadenosines having a platelet aggregation inhibitory activity and a coronary vasodilating activity, which comprises reacting 5-amino-1-.beta.-D-ribofuranosylimidazole-4-carboxamide oxime or an O-substituted oxime thereof with carbon disulfide in a closed reaction zone at a temperature of from about 50.degree. to about 200.degree. C in a solvent.

REFERENCES:
patent: 3872082 (1975-03-01), Bergmeyer et al.
Cresswell, et al. "J. Org. Chem.", 28 p. 2560, 1963.
Yamazaki, et al. J. Org. Chem. 32, p. 3032, 1967.

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