Process for preparing 2-halo-5-substituted pyridines

Details Process for preparing 2-halo-5-substituted pyridines Process for preparing 2-halo-5-substituted pyridines

1993-11-30

1996-04-16

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546253, C07D21361

Patent

active

055084109

ABSTRACT:
Described are preferred processes for preparing 2-halo-5-substituted pyridine compounds. Preferred processes can be conducted in a one-step, one-pot fashion, and involve the reaction of a formamide and a halogenating agent with a nitrile such as cis-2-pentenonitrile or with a combination of reactants including an aldehyde such as n-propionaldehyde and a nitrile or an amide. Preferred processes provide for convenient and advantageous preparations of 2-chloro-5-methylpyridine, which serves as an intermediate to important insecticidal compounds.

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