Process for preparing 2'-(diethylamino)rifamycin P (P/DEA)

Details Process for preparing 2'-(diethylamino)rifamycin P (P/DEA) Process for preparing 2'-(diethylamino)rifamycin P (P/DEA)

1993-10-08

1995-01-03

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540457, 540458, A61K 31395, C07D51318

Patent

active

053788370

ABSTRACT:
The present invention relates to a new one-pot process for preparing 2'-(diethylamino)rifamycin P and its 25-desacetyl derivative which consists in cyclizing 3-bromorifamycin S or its 25-desacetyl derivative, dissolved in dimethylformamide, with 1,1-diethylthiourea and reducing, without isolation, the obtained 1,2-quinonimine intermediate with a mild reducing agent.

REFERENCES:
patent: 4116957 (1978-09-01), Rossetti et al.
patent: 4129562 (1978-12-01), Cricchio
patent: 4144234 (1979-03-01), Cricchio
Journal of Medicinal Chemistry, vol. 33, No. 5, (1990), Synthesis and Biological Activity of Some Derivatives of Rifamycin P, Cavalleri, et al., Washington US pp. 1470-1476.
Journal of American Chemical Society; 98:22; Oct. 27, (1976); Substituent Effects on the Solution Conformation of Rifamycin S; M. F. Dampier, et al., pp. 7064-7069.
Bactericidal Activity in Vito of Various Rifamycins against Mycobacterium avium and Mycobacterium tuberculosis; Heifets, et al.

Affiliated with

Also associated with

Rating

Process for preparing 2'-(diethylamino)rifamycin P (P/DEA) does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing 2'-(diethylamino)rifamycin P (P/DEA), we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing 2'-(diethylamino)rifamycin P (P/DEA) will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2212563