Process for preparing 2-alkyl-4-amino-5-aminomethylpyrimidine

Details Process for preparing 2-alkyl-4-amino-5-aminomethylpyrimidine Process for preparing 2-alkyl-4-amino-5-aminomethylpyrimidine

1984-03-26

1985-08-20

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

564397, 564398, 564472, 564473, C07D23902

Patent

active

045365776

ABSTRACT:
Disclosed is a process for preparing 2-alkyl-4-amino-5-aminomethylpyrimidine comprising (i) a first step of reacting 2-alkyl-4-amino-5-formylpyrimidine with ammonia in an inert solvent in the presence of at least one compound selected from heteropolyacids, isopolyacids, oxyacids and salts thereof containing molybdenum or tungsten, and (ii) a second step of reacting the reaction product in the first step catalytically with ammonia and hydrogen in an inert solvent in the presence of a reducing catalyst together with or without a hydroxide of an alkali metal or alkaline earth metal.

REFERENCES:
patent: 3223734 (1965-12-01), Fallstad et al.
patent: 4210605 (1980-07-01), Hoshino et al.
Winans, JACS 61, 3566, (1939).
Synthetic Organic Chem. by Wagner et al, 1953, pp. 662, 663, 656.
March, Advanced Org. Chem., 2nd Edition, 1977, p. 819.

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