Process for preparing 2-acetythio-3-phenyl-propionic acid and th

Details Process for preparing 2-acetythio-3-phenyl-propionic acid and th Process for preparing 2-acetythio-3-phenyl-propionic acid and th

1999-02-17

2000-06-27

Marschel, Ardin H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Esters having the thiocarboxylate group, -cx-, wherein the...

C07C15309

Patent

active

060808810

ABSTRACT:
It is described a process for preparing 2-acetylthio-3-phenyl-propionic acid and the salts thereof starting from 2-bromo-3-phenyl-propionic acid and potassium thioacetate in an organic solvent and in the presence of a phase transfer catalyst.

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Synthesis of C.sub.2 -Symmetric HIV Protoase Inhibitors With Sulfur-Containing Control Units; Andrew Spaltenstein et al.; Tetrahedron Letters, vol. 34, No. 9, pp. 1457-1460. 1993.
"Synthesis of (Racemization Prone) Optically Active Thiols by S.sub.N 2 Substitution Using Cesium Thiocarboxylates";Bert Strijtveen et al.; J. Org. Chem. 1986; vol. 51; pp. 3664-3671.

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