Process for preparing 2-(6-methoxy-2-naphthyl)propionic acid

Details Process for preparing 2-(6-methoxy-2-naphthyl)propionic acid Process for preparing 2-(6-methoxy-2-naphthyl)propionic acid

1974-02-21

1976-08-17

Morgenstern, Norman

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2604299, 260473A, C07C 5109, C07C 6700

Patent

active

039754324

ABSTRACT:
2-(6-Methoxy-2-naphthyl)propionic acid is prepared by reacting di(6-methoxy-2-naphthyl)-zinc or 6-methoxy-2-naphthylzinc halide with a lower alkyl 2-halopropionate in a suitable solvent to form a lower alkyl 2-(6-methoxy-2-naphthyl)propionate and hydrolyzing the ester group thereof. The product has anti-inflammatory, analgesic and anti-pyretic activities.

REFERENCES:
patent: 3658858 (1972-04-01), Harrison
patent: 3658863 (1972-04-01), Harrison
patent: 3663584 (1972-05-01), Alvarez
March "Advanced Organic Chemistry", McGraw Hill Book Co. (1968) pp. 353-354.
Gilman, Organic Chemistry vol. I, Wiley & Sons, Inc. (N.Y.) (1958) pp. 539-549.
Buehler et al., Survey of Organic Synthesis, Wiley-Interscience (NY) Dec. 11, 1970 pp. 22-29.
Shevendina et al. The Organic Compounds of Zinc and Cadmium, North-Holland Pub. Co. (1967) pp. 2, 73-78.
Shevendina et al., Doklady Akad. Nauk. S.S.S.R. 124 602-605 (1959).
Delarve C.A. 72 42721c.

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