Process for preparing 2,6-diaminopurine derivatives

Details Process for preparing 2,6-diaminopurine derivatives Process for preparing 2,6-diaminopurine derivatives

2005-05-24

2005-05-24

Berch, Mark L. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

active

06897307

ABSTRACT:
A one-pot process for preparing 2,6-diaminopurine derivatives or an acid addition salt thereof comprising: (i) reacting a purine compound with an amine compound in the presence of a tertiary amine at a pH of 7 to 14 to form a 6-substituted aminopurine derivative, and (ii) reacting the 6-substituted aminopurine with an aromatic amine in the presence of an acid catalyst at a pH of 0.1 to less than 7.

REFERENCES:
patent: 4954504 (1990-09-01), Chen et al.
patent: 0109134 (2001-02-01), None
Kelley et al., “Synthesis and Structure-Activity Relationships of 2-Substituted-6-(dimethylamino)-9-(4-methylbenzyl)-9H-purines with Antirhinovirus Activity”, J. Med. Chem., vol. 32, pp. 218-224 (1989).
Nugiel et al., “Facile Preparation of 2,6-Disubstituted Purines Using Solid-Phase Chemistry”, J. Org. Chem., vol. 62, pp. 201-203 (1997).
Brill et al., “Solid-Phase Synthesis of 2,6,8-Trisubstituted Purines”, Tetrahedron Letters, vol. 42, pp. 6515-6518 (2001).

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