Process for preparing 2(4-fluorophenyl)alpha-methyl-5-benzoxazol

Details Process for preparing 2(4-fluorophenyl)alpha-methyl-5-benzoxazol Process for preparing 2(4-fluorophenyl)alpha-methyl-5-benzoxazol

1985-10-07

1987-03-24

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D26356

Patent

active

046526544

ABSTRACT:
A process for preparing 2(4-fluorophenyl).alpha.-methyl-5-benzoxazole acetic acid starting from 4-hydroxy-3-amino-phenylacetic acid, which is firstly reacted with 4-fluorobenzoyl chloride, and the product obtained is reacted with phosphoric acid; the 2(4-fluorophenyl)5-benzoxazole acetic acid obtained in this manner is esterified with ethyl alcohol, and the ester is treated with diethyloxalate; the ethyl 2(4-fluorophenyl)5-benzoxazole oxalacetate obtained is reacted with formaldehyde and potassium carbonate to obtain ethyl 2(4-fluorophenyl)5-benzoxazole acrylate, which is hydrolysed to obtain the corresponding acid, from which the 2(4-fluorophenyl).alpha.-methyl-5-benzoxazole acetic acid is obtained by hydrogenation.

REFERENCES:
patent: 3912748 (1975-10-01), Evans et al.
patent: 3962452 (1976-06-01), Evans et al.
patent: 4025636 (1977-05-01), Dunwell et al.
Ambros et al., Chem. Abst. 99-70710z.
Botija Menchero et al., Chem. Abst. 104-88520u.
Signorini et al., Chem. Abst. 100-209792n.
Cockerill et al., Chem. Abst. 86-139910r.
Evans, Chem. Abst. 85-142806w.
International Pharmaceutical Patents Co., Chem. Abst 89-24287n.
Ravizza S.p.A., Chem. Abst. 93-26426p.
Stampa, Chem. Abst. 97-182392n.
Dunwell et al., Chem. Abst. 83-97265q.
Dunwell et al., Chem. Abst. 82-118774b.
Evans, Chem. Abst. 80-70798s.
Duran et al., Chem. Abst. 98-160693e.
International Pharmaceutical Patents Co., Chem. Abst. 89-24287n.
Dunwell et al., J. Med. Chem. 1975, vol. 18, No. 1, 53-58.

Affiliated with

Also associated with

Rating

Process for preparing 2(4-fluorophenyl)alpha-methyl-5-benzoxazol does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing 2(4-fluorophenyl)alpha-methyl-5-benzoxazol, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing 2(4-fluorophenyl)alpha-methyl-5-benzoxazol will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1354746