Process for preparing 2,4-diamino-pyrimidines

Details Process for preparing 2,4-diamino-pyrimidines Process for preparing 2,4-diamino-pyrimidines

1978-12-08

1981-03-10

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544325, C07D23948

Patent

active

042555744

ABSTRACT:
A process for preparing a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are lower alkoxy or taken together are methylenedioxy; R.sub.3 is lower alkyl or hydrogen, which comprises the step of reacting an aromatic compound of the formula ##STR2## wherein R.sub.1, R.sub.2 and R.sub.3 are as previously described, with a diamino-pyrimidine of the formula ##STR3## wherein R.sub.4 is lower alkoxy, benzyloxy, hydroxy or halogen, in the presence of an inorganic or organic acid selected from the group consisting of ortho-phosphoric acid, poly-phosphoric acid, hydrohalic acids and tri-haloacetic acids, at a temperature in the range of from about 50.degree. C. to about 110.degree. C., is described.

REFERENCES:
patent: 2487569 (1948-07-01), Mackey
patent: 4116958 (1978-09-01), Stuart et al.

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