Process for preparing 2-(4-aminophenyl)-5-amino-benzimidazole an

Details Process for preparing 2-(4-aminophenyl)-5-amino-benzimidazole an Process for preparing 2-(4-aminophenyl)-5-amino-benzimidazole an

1982-03-11

1983-11-22

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23518

Patent

active

044170564

ABSTRACT:
The invention concerns a process for the preparation of 2-(4-aminophenyl)-5-aminobenzimidazole and substituted derivatives by catalytic cycloreduction of starting material N-(4-nitrobenzoyl)-2,4-dinitroaniline or a substituted derivative by hydrogen gas. According to the invention, the starting material is treated in suspension in an aqueous solution of hydrochloric or phosphoric acid, the content (C) of starting material in said suspension ranging from 0.15 to 1.5 mole per liter and the molar ratio (A): acid/starting material being from 2 to 20. The process is carried out at a hydrogen pressure from 5 to 100 bars and a temperature (T) from 20.degree. to 150.degree. C. selected so that the product T.times.A.times.C is equal to or greater than 25. There is thereby obtained a product of excellent purity with very good yields.

REFERENCES:
patent: 4109093 (1978-08-01), Arsac et al.
patent: 4192947 (1980-03-01), Bauer et al.
European Patent Application, No. 1, 246, (4-4-79).
Brown, Chemical Abstracts, vol. 59, (1963), p. 10065a.
Porai-Koshits et al., Chemical Abstracts, vol. 52, (1958), p. 17240.

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