Process for preparing 2,4,5,6-tetraaminopyrimidine sulfate

Details Process for preparing 2,4,5,6-tetraaminopyrimidine sulfate Process for preparing 2,4,5,6-tetraaminopyrimidine sulfate

1979-09-28

1981-01-27

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23950

Patent

active

042476933

ABSTRACT:
A process for preparing 2,4,5,6-tetraaminopyrimidine sulfate is disclosed. The process comprises: (1) reacting about one molecular proportion of 5-nitroso-2,4,6-triaminopyrimidine (NTAP) in water with about 2.0 to 2.5 molecular proportions of zinc dust and about 4.0 to 4.7 molecular proportions of a suitable acid, to provide a reaction mixture having a pH below 7; (2) reacting the reaction mixture at a temperature of about 20.degree. to 65.degree. C. to form the acid salt of 2,4,5,6-tetraaminopyrimidine; (3) adjusting the pH to about 2.0 to 2.5 by adding the suitable acid to form a solution of the acid salt; (4) separating the insoluble materials from step (3) to obtain a wet cake and a mother liquor; (5) adding sulfuric acid to the mother liquor to adjust the pH to about 0.2 to 0.5 while maintaining the temperature at about 20.degree. to 60.degree. C.; (6) cooling the reaction mixture of step (5) to about 0.degree. to 10.degree. C. to precipitate 2,4,5,6-tetraaminopyrimidine sulfate; and (7) recovering the precipitate.

REFERENCES:
patent: 2473802 (1949-06-01), Kuh et al.
patent: 3111521 (1963-11-01), Hoefle et al.
patent: 4003699 (1977-01-01), Rose et al.
patent: 4167633 (1979-09-01), Morrow
"J. Chem. Soc." (1953), p. 3721.
"J. Amer. Chem. Soc.", vol. 69, 1947, p. 1814.
"J. Amer. Chem. Soc.", vol. 55, 1933, p. 1667.
"Berichte", vol. 37, 1904, p. 4544.

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