Process for preparing 2,3-disubstituted indoles

Details Process for preparing 2,3-disubstituted indoles Process for preparing 2,3-disubstituted indoles

2009-06-19

2010-12-14

Saeed, Kamal A (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C546S277400, C548S305100, C548S510000

Reexamination Certificate

active

07851625

ABSTRACT:
Disclosed are processes for making 2, 3 disubstituted indole compounds such as compounds of general formula I comprised of the steps ofa) reacting a bromoindole compound (i) with a dialkoxyl C1-5borane in the presence of a ligand, a palladium catalyst and a base to make a compound of general formula (ii); or alternatively reacting compound (i) with a trialkyl magnesiate reagent, followed by treatment with a borate;b) reacting the product of step a with a R2-Hal where R2-Hal is defined herein.

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