Process for preparing 2' -0- alkyl adenosine derivatives

Details Process for preparing 2' -0- alkyl adenosine derivatives Process for preparing 2' -0- alkyl adenosine derivatives

1995-06-07

1997-01-21

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 276, C07H 100, C07H 19167

Patent

active

055960944

ABSTRACT:
A process for alkylating the 2'-OH of N.sup.6 -modified adenosine comprising the reacting of an unprotected N.sup.6 -alkyl adenosine with dimethyl sulfate and tetrabutylammonium hydrogen sulfate in a non-polar solvent, preferably dichloromethane, and 5% sodium hydroxide. The products of the reaction are useful as anti-diabetic, hypolipidemic, and analgesic agents.

REFERENCES:
patent: 4843066 (1989-06-01), Yamada et al.
patent: 4985409 (1991-01-01), Yamada et al.
Manoharan et al. Tetrahedron Letters 32(49):7/71-7/74, 1991.
Wagner et al Nucl. Acids Res. 19(21):5965-5971, 1991.
Sproat et al. Nucl. Acids Res. 19(4):733-738, 1991.
Robins et al. Can. J. Chem. 59:3360-3364, 1981.
Merz, Andreas Angew. Chem. 85(19):868-869, 1973.

Affiliated with

Also associated with

Rating

Process for preparing 2' -0- alkyl adenosine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing 2' -0- alkyl adenosine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing 2' -0- alkyl adenosine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2325171