Process for preparing 10-deazaminopterins

Details Process for preparing 10-deazaminopterins Process for preparing 10-deazaminopterins

1982-01-22

1984-02-21

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Plural nitrogens bonded directly to the pteridine ring system

C07D47508

Patent

active

044331479

ABSTRACT:
A process and composition are provided employing 10-deazaminopterin and 10-alkyl derivatives therefor for the treatment of leukemia, as well as other tumor systems including those of ascitic character, and also a process for preparing 10-deazaminopterin compounds.

REFERENCES:
De Graw et al., J. Med. Chem., 1974, vol. 17, No. 5, pp. 552-553.
DeGraw et al., J. Med. Chem., 1971, vol. 14, No. 9, pp. 866-867.

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