Process for preparing 1-substituted 8-chloro-7-fluoro-9-methyl-4

Details Process for preparing 1-substituted 8-chloro-7-fluoro-9-methyl-4 Process for preparing 1-substituted 8-chloro-7-fluoro-9-methyl-4

1996-10-23

1998-08-04

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D45502

Patent

active

057895910

ABSTRACT:
A process for preparing a compound having the formula: ##STR1## wherein R is selected from the group consisting of C.sub.3 -C.sub.6 -cycloalkyl, C.sub.3 -C.sub.6 -cycloalkylmethyl, C.sub.1 -C.sub.6 -alkyl, allyl and 2-methoxyethyl, by reacting: ##STR2## under defined conditions with subsequent stepwise reactions of the respective intermediate compounds with a malonic acid diester, POCl.sub.3, and by heating the final intermediate in a high boiling solvent.

REFERENCES:
Caine, D., "Alkylations of Enols and Enolates", Alkylation of Carbon, University of Alabama, Tuscaloosa, AL, pp. 1-63, 1991.
Stork, G., et al., "Alkylations of Aldehydes vai Reaction of the Magnesioneamine Salt of an Aldehyde: 2,2-Dimethyl-3-Phenylpropionaldehyde", Organic Syntheses, vol. 54, pp. 46-49, 1974.
Stork, G., et al., "A New Method for the Alkylation of Ketones and Aldehydes: the C-Alkylation of the Magnesium Salts of N-Substituted Imines", Communication to the Editor, vol. 85, Jul. 20, 1963, pp. 2178-2180.
Whitsell, J., et al., "Alkylation of Ketones and Aldehydes via their Nitrogen Derivatives", Synthesis, Jul. 1983, pp. 517-536.
Mar. J. Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, 4th edition, p. 470, Jun. 1993.

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