Process for preparing 1-pyruvyl-L-proline

Details Process for preparing 1-pyruvyl-L-proline Process for preparing 1-pyruvyl-L-proline

1998-08-06

1999-04-27

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548579, 548535, C07D20708, C07D20706

Patent

active

058980768

ABSTRACT:
Process for preparing N-pyruvyl-L-proline by reaction of L-proline with methyl pyruvate dimethyl ketal in the presence of an alkali metal alkoxide, subsequent acid hydrolysis and extraction of 1-pyruvyl-L-proline.

REFERENCES:
patent: 5424454 (1995-06-01), Burbaum et al.
Soai et al., Diastereoselective Reduction of Chiral . . . , J. Chem. Soc. Perkin Trans. 1 (4) 769-772., Dec. 1985.
N. Krit et al., translation from Khimiki-farmatsevitcheskii Zhurnal, 25 (7), 46-49 (Jul. 1991).
G. Jou et al., J. Org. Chem., 62 (2), 354-366 (1997).

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