Process for preparing 1-phenyl-2-amino-3-fluoro-1-propanols

Details Process for preparing 1-phenyl-2-amino-3-fluoro-1-propanols Process for preparing 1-phenyl-2-amino-3-fluoro-1-propanols

1994-05-10

1996-10-22

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

548237, 548239, C04D26310, C07C23110, C07C23305

Patent

active

055678440

ABSTRACT:
Replacement with fluorine of the primary hydroxy group of 1-phenyl-2-amino-1,3-propanediol compounds wherein the secondary hydroxy group and the amino group have been suitably protected.
The reaction is carried out with an inorganic fluoride in a polyglycol.
New oxazoline compounds particularly useful in said process.

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Michael R. C. Gerstenberger and Alois Haas. "Methods of Fluorination in Organic Chemistry". Angew. Chem. Int.Ed.Engl., vol. 20, pp. 647 and 659. 1981.
Eugen Mueller, O. Bayer, H. Meerwein and K. Ziegler. "Halogen-Verbindungen". Methoden Der Organischen Chemie, Band V/3, pp. 166-169. 1962.

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