Process for preparing (1-oxo-2-phenyl, halophenyl or thienyl-2-m

Details Process for preparing (1-oxo-2-phenyl, halophenyl or thienyl-2-m Process for preparing (1-oxo-2-phenyl, halophenyl or thienyl-2-m

1974-07-30

1976-09-21

Thomas, Jr., James O.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603323P, 260590FA, 424275, 424331, C07D33324

Patent

active

039818888

ABSTRACT:
Process for preparing (1-oxo-2-phenyl, halophenyl or thienyl-2-methyl-6,7-dichloro-5-indanyloxy)acetic acid, pharmaceutically acceptable salt, ester and amide derivatives thereof and intermediate 5-ether derivatives thereof comprising reacting under Friedel-Crafts conditions a 2-phenyl, halophenyl or thienyl-2-propionyl halide or an anhydride thereof with an ether derivative of 2,3-dichlorophenyl; and reacting the resulting propiophenone with formaldehyde in the presence of acid to yield the desired indanone.

REFERENCES:
patent: 3704314 (1972-11-01), Cragoe et al.
patent: 3784606 (1974-01-01), Holland et al.
Cragoe "Chemical Abstracts" vol. 73, (1970), pp. 25180d, 25182f.

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