Process for preparing [1-oxo-2-cyclopentyl (or 2-isopropyl)-2-me

Details Process for preparing [1-oxo-2-cyclopentyl (or 2-isopropyl)-2-me Process for preparing [1-oxo-2-cyclopentyl (or 2-isopropyl)-2-me

1974-02-15

1976-04-13

Terapane, John F.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260473F, 260473G, 260521H, 260559B, 260592, 424308, 424317, 424324, 260590R, C07C 6520

Patent

active

039504085

ABSTRACT:
Process for preparing [1-oxo-2-cyclopentyl(or 2-isopropyl)-2-methyl-6,7-dichloro-5-indanyloxy]acetic acid, pharmaceutically acceptable salt, ester and amide derivatives thereof and intermediate 5-ether derivatives thereof comprising reacting under Friedel-Crafts conditions a 2-cyclopropyl-or 2-isopropylpropionyl halide or an anhydride thereof with an ether derivative of 2,3-dichlorophenol; and reacting the resulting propiophenone with formaldehyde in the presence of acid to yield the desired indanone.

REFERENCES:
March, "Advanced Organic Chemistry," McGraw-Hill Co., (N.Y.), 1968, pp. 406-416.
Beilstein, Band VII, p. 360 (1925).
Fuson et al., J. Am. Chem. Soc., 60 2935 (1938).

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