Process for preparing 1-hydroxyalkyl-5-nitroimidazoles

Details Process for preparing 1-hydroxyalkyl-5-nitroimidazoles Process for preparing 1-hydroxyalkyl-5-nitroimidazoles

1989-01-13

1990-05-15

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548336, 548339, 548340, C07D23394, C07D40506

Patent

active

049259520

ABSTRACT:
Process for preparing 1-(hydroxyalkyl)nitroimidazoles of formula: ##STR1## which comprises reacting an alkylene sulphate of formula: ##STR2## with an imidazole derivative of formula: ##STR3## followed by hydrolyzing or alcoholyzing the product obtained. In the formulae (I) and (II), n is 2 or 3; in the formulae (I) and (III), R denotes hydrogen or hydrocarbon radical; and in the formula (III), X denotes hydrogen or a radical that can be removed by hydrolysis or alcoholysis.

REFERENCES:
patent: 3178446 (1965-04-01), Sannicolo
patent: 3743653 (1973-07-01), Marburg
Chemical Abstracts, 77:139490t, (1972), [D. Tomalia, et al., J. Heterocycl. Chem., 1972, 9(4), pp. 891-894].

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