Process for preparing 1-hydroxyalkyl-5-nitroimidazole

Details Process for preparing 1-hydroxyalkyl-5-nitroimidazole Process for preparing 1-hydroxyalkyl-5-nitroimidazole

1989-01-13

1990-05-15

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548336, 548339, 548340, C07D23394, C07D40506

Patent

active

049259504

ABSTRACT:
Hydroxyalkylating agents of formula: ##STR1## in which R denotes alkyl, n is 2 or 3, R.sub.1 denotes hydrogen or alkyl and R.sub.2 denotes alkyl an unsubstituted or substituted phenyl or ##STR2## are useful inter alia for the preparation of 1-(hydroxyalkyl)imidazoles. They are made by reaction of a sulphonic acid or dimethyl sulphate with a corresponding decarboxylate ester.

REFERENCES:
Fieser, L. et al., Reagents for Organic Synthesis, John Wiley, New York, 1967, pp. 294-295.
Chemical Abstracts, 77:139490t (1972), [D. Tomalia et al., J. Heterocycl. Chem., 1972, 9(4), 891-4].

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