Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-11-07
1996-12-03
Haley, Jacqueline
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D40304
Patent
active
055809871
ABSTRACT:
There is disclosed a process for the preparation of 1-aminoacetamidopyrroles and 1-amino-2-(substituted)-pyrroles and related compounds of the formula ##STR1## wherein all substituents are defined herein, which are useful as glycine partial agonists and for the enhancement of learning and memory and for the treatment of memory dysfunctions associated with neurodegenerative disorders and are thus indicated in the treatment of Alzheimer's disease and other senile dementias which comprises treating a 1-phthalimidopyrrole of the formula ##STR2## with a base to yield a 1-aminopyrrole of the formula ##STR3## which is reacted with a compound of the formula ##STR4## to obtain the compound of Formula (I).
REFERENCES:
patent: 4517195 (1985-05-01), Effland et al.
Flanagan Denise M.
Kosley, Jr. Raymond W.
Kuerzel Gert U.
Martin Lawrence L.
Nemoto Peter A.
Dixon J. Michael
Haley Jacqueline
Hoechst Marion Roussel Inc.
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