Process for preparing 1.alpha.-hydroxylated compounds

Details Process for preparing 1.alpha.-hydroxylated compounds Process for preparing 1.alpha.-hydroxylated compounds

1979-05-21

1981-04-07

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603971, C07J 900

Patent

active

042605490

ABSTRACT:
An improved method for the preparation of 1.alpha.-hydroxylated vitamin D compounds involving directly introducing an oxygen function at carbon 1 of the vitamin D molecule or precursors or derivatives thereof, wherein the 1.alpha.-hydroxycyclovitamin D intermediate is solvolyzed directly, without first converting the 1-hydroxy group to a 1-O-acyl function as a protective measure.

REFERENCES:
patent: 3743661 (1973-07-01), De Luca et al.
patent: 3887545 (1975-06-01), Iacobelli et al.
patent: 4038272 (1977-07-01), Partridge, Jr. et al.
patent: 4179452 (1979-12-01), Ochi et al.
Paaren et al., Proc. Natl. Acad. Sc. USA, vol. 75, No. 5, pp. 2080-2081 (May 1978). _
Napoli et al., "Steroids" vol. 32, No. 4 (Nov. 1978) pp. 453-465. _
PCT-International Publication No. WO/79/00513, Aug. 9, 1979. _
"Steroids" Aug. 1977, article by Pele, pp. 193-200. _

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