Process for preparing 1,5-benzothiazepine derivative

Details Process for preparing 1,5-benzothiazepine derivative Process for preparing 1,5-benzothiazepine derivative

1991-11-27

1992-12-08

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

A61K 3155, C07D28110

Patent

active

051699460

ABSTRACT:
A process for preparing hydrochloride of 3-acetoxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(p-methoxyphenyl)-1,5-b enzothiazepin-4(5H)-one which comprises reacting 3-hydroxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(p-methoxyphenyl)-1,5-b enzothiazepin-4(5H)-one which acetyl chloride in acetic acid or a mixed solvent of acetic acid and acetic anhydride. According to the process, hydrochloride of 3-acetoxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(p-methoxyphenyl)-1,5-b enzothiazepin-4(5H)-one is readily obtained in one step.

REFERENCES:
patent: 3562257 (1971-02-01), Kugita et al.
patent: 4590188 (1986-05-01), Takeda et al.
Chemical Abstracts, vol. 107, No. 21, Nov. 23, 1987, Columbus, Ohio, U.S.; abstract No. 198367U, p. 770; abstract.
"Brief Comments on Relevant Arts", which contains comments concerning each of the above listed Japanese Patent Publications 813/1972, 18038/1978, and 132876/1987.

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