Process for preparing 1-(3-trialkylsilylphenyl)-2,2,2-trifluorom

Details Process for preparing 1-(3-trialkylsilylphenyl)-2,2,2-trifluorom Process for preparing 1-(3-trialkylsilylphenyl)-2,2,2-trifluorom

1996-06-18

1998-06-02

Shaver, Paul F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Silicon containing

C07F 708

Patent

active

057602670

ABSTRACT:
The present invention relates to a novel process for the preparation of 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanones from 1-halo-3-trialkylsilanyl-benzenes. 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanones are useful for the treatment of Alzheimer's disease and senile dementia. In addition, the present invention relates to a novel process for purifying 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanones utilizing a novel extraction method.

REFERENCES:
patent: 5523442 (1996-06-01), Collard et al.
patent: 5554780 (1996-09-01), Wolf
patent: 5606089 (1997-02-01), Tamura et al.
patent: 5679820 (1997-10-01), Pickett et al.
deNanteuil, G., Tetrahedron Letters, vol. 32, No. 22, pp. 2467-2468 (1991).
L.S. Chen, et al., J. of Fluorine Chemistry, 18, pp. 117-129 (1981).
G.Chen, et al., J. of Organometallic Chemistry, 251, pp. 149-158 (1983).
K.T. Dishart, et al.,J. of the American Chemical Society, vol. 78, pp. 2268-2270 (1956).
A.Sykes, et al., J. of the Chemical Society, pp. 835-839 (1953).
J-M Hornsperger, et al., Biochemical Society Transactions vol. 22, pp. 758-763 (1994).
X.Creary, J. Org. Chem. 52, pp. 5026-5030 (1987).
B. Hassine, et al., Bull. Soc. Chim. Belg. vol. 95
, pp. 547-556 (1986).

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