Process for preparing 1-(3-bromo-2-alkylpropanoyl-L-proline deri

Details Process for preparing 1-(3-bromo-2-alkylpropanoyl-L-proline deri Process for preparing 1-(3-bromo-2-alkylpropanoyl-L-proline deri

1981-02-20

1982-09-14

Fan, Jane T.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26032611R, 2602393B, C07D20716, C07D20918

Patent

active

043494803

ABSTRACT:
The invention relates to the preparation of 1-bromo-2-D-alkylpropanoyl-L-proline derivatives and analogous compounds which are useful as chemical intermediates to angiotensin converting enzyme (ACE) inhibitors and to the stereospecific synthesis of such ACE inhibitors having the formula: ##STR1## wherein R.sup.1 is lower alkyl and R.sup.4 and R.sup.5 are both hydrogen or together with the carbons to which they are attached represent a benzene ring optionally substituted by defined substituents. Intermediates of formula ##STR2## are also disclosed wherein R.sup.1, R.sup.4, R.sup.5 are as defined above and B.sup.+ is a cation.

REFERENCES:
patent: 4105776 (1978-08-01), Ondetti et al.
patent: 4127535 (1978-11-01), Coy et al.
patent: 4129566 (1978-12-01), Ondetti et al.
patent: 4154935 (1979-05-01), Ondetti et al.
patent: 4192945 (1980-03-01), Ondetti
patent: 4291040 (1981-09-01), Krapcho
Buehler et al., Survey of Organic Synthesis, John Wiley & Sons Inc., 1970, p. 896.
March, Advanced Org. Chem. Reactions, Mechanisms and Structure, p. 81.

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