Process for preparing 1-(3,5-dimethoxy-4-hydroxy phenyl)-2-(N-me

Details Process for preparing 1-(3,5-dimethoxy-4-hydroxy phenyl)-2-(N-me Process for preparing 1-(3,5-dimethoxy-4-hydroxy phenyl)-2-(N-me

1981-11-02

1983-10-04

Hines, Robert V.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

260511, 564343, 564344, 564356, 564357, 568764, 568765, C07C 9116

Patent

active

044080743

ABSTRACT:
A process for preparing 1-(3,5-dimethoxy-4-hydroxy phenyl)-2-(N-methylamino) ethanol hydrochloride is described by reacting 2,6-dimethoxyphenol with anhydrous chloral in the presence of a catalyst, hydrolyzing 1-(3,5-dimethoxy-4-hydroxyphenyl)2,2,2-trichloro ethanol and subsequently isolating the 3,5-dimethoxy-4-hydroxyphenyl glyoxal thus obtained; finally, this compound, in the form of the bisulfite, is directly converted to the desired product by amination with methylamine in the presence of hydrogen with a hydrogenation catalyst and the final product is converted into the hydrochloride.

REFERENCES:
patent: 3642896 (1972-02-01), Collin

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