Process for preparing 1,2-propanediol derivative compounds

Details Process for preparing 1,2-propanediol derivative compounds Process for preparing 1,2-propanediol derivative compounds

1997-03-11

1998-11-24

Richter, Johann

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435155, 435156, 435157, 568858, C07C 2700, C12P 704, C12P 722, C12P 724

Patent

active

058405534

ABSTRACT:
A novel glycerol derivative, a process for preparing the same, and a process for preparing a triazole derivative. An optically active 2-arylglycerol derivative which is novel and useful as a synthetic intermediate of medicament is provided, and furthermore, (R)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazole-1-yl)-propane-1,2-diol, which is useful as an antifungal agent, is prepared.

REFERENCES:
patent: 4921798 (1990-05-01), Boaz
patent: 4931399 (1990-06-01), Sih
Atsuumi et al, "An Efficient Enantioselective Preparation of 2-Substituted-3-Hydroxypropionic acids via Chemo-Enzymatic Reaction", Tetrahedron Letters, vol. 31, No. 11, pp. 1601-1604, 1990, Great Britain.
Tsuji et al, "Lipase-Catalyzed Asymmetric Synthesis of Chiral, 1,3-Propanediols and its Application to the Preparation of Optically Pure Building Block for Renin Inhibitors", Tetrahedron Letters, vol. 30, No. 45, pp. 6189-6192, 1989, Great Britain.
Suemune et al, "Enzymatic Synthesis of 2,3-O-Isopropylidene-sn-glycerol, a Chiral Building Block for Platelet-Activating Factor", Chem. Pharm. Bull., vol. 34 (1986), pp. 3440-3444.
Guanti et al, "Enzyme Catalyzed Monohydrolysis of 2-Aryl-1,3-Propanediol Diacetates. A Study of Structural Effects of the Aryl Moiety on the Enantioselectivity", Tetrahedron, vol. 46, No. 20, pp. 7081-7092, 1990, Great Britain.
Tombo et al, "Synthesis of Both Enantiomeric Forms of 2-Substituted 1,3-Propanediol Monoacetates Starting From a Common Prochiral Precursor, Using Enzymatic Transormations in Aqueous and in Organic Media", Tetrahedron Letters, vol. 27, No. 47, pp. 5707-5710, 1986, Great Britain.
Guanti et al, "Enzymatic Asymmetrization of Some Prochiral and Meso Diols through Monoacetylation with Pig Pancreatic Lipase (PPL)", Tetrahedron: Asymmetry, vol. 5, No. 1, pp. 9-12, 1994, Elsevier Science Ltd., Great Britain.
Lovey et al, "PPL-Catalyzed Enzymatic Asymmetrization of a 2-Substituted Prochiral 1,3-Diol With Remote Chiral Functionality: Improvements Toward Synthesis of the Eutomers of SCH 45012", Tetrahedron Letters, vol. 35, No. 33, pp. 6047-6050, 1994, Great Britain.
Didier et al, "Chemo-Enzymatic Synthesis of 1,2- and 1,3- Amino-Alcohols and their use in the Enantioselective Reduction of Acetophenone and Anti-Acetophenone Oxime Methyl Ether with Borane", Tetrahedron, vol. 47, No. 27, pp. 4941-4958, 1991, Great Britain.
ICI-D0870, "Triazole Antifungal", Drugs of the Future 1993, 18(5): pp. 424-427.
Blundell et al, "Synthesis of Novel Azole Antifungals by a Modified Sharpless Asymmetric Dihydroxylation", Synlett, Apr. 1964, pp. 263-265.
Guanti et al, "Chemoenzymatic Preparation of Asymmetrized Tris(hydroxymethl)-methane (THYM*) and of Asymmetrized Bis(hydroxymethyl)acetaldehyde (BHYMA*) as New Highly Versatile Chiral Building Blocks", J. Org. Chem., 1992, 57, pp. 1540-1554.
Gonzalez et al, "Thymol Derivatives from Schizogyne Glaberrima", Phytochemistry, vol. 25, No. 12, pp. 2289-2891 (1986).
Bohlmann et al., "New Guaianolides From Centipeda Minima", Kexue Tongbao. vol. 29, No. 7, pp. 900-903 (Jul. 1984).

Affiliated with

Also associated with

Rating

Process for preparing 1,2-propanediol derivative compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing 1,2-propanediol derivative compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing 1,2-propanediol derivative compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1700862